Delegations
This is really a question of personal preference. Click on the left hand side menu on "Settings" and toggle the CPU buttons as preferred. Don't forget to click on save changes after deciding.
Coach handling determines whether you can hire and fire your co-ordinators in the post-season. This isn't a major job to take control of, so I like to keep assistance off in this area.
Personally the vast majority of my fun comes from handling recruitment, so I'm definitely not having interference in that area!
Future schedules determines (for the most part in 0.8.5) whether assistants will arrange future games outside your conference. I'll cover this in a separate post below, but when I was starting out I left turned CPU assistance on and took over after a couple of seasons. (Even with this turned off, I would occasionally get emails to respond to asking if I wanted to agree or decline a request for a game – I'm assuming that this is where my team couldn't decide, so passed it up to me)
Disciplinary action determines whether you control punishments for students breaking rules. Punishments can range from a warning, to suspended from the team for up to 7 weeks. The college itself can also suspend for certain activities, which will automatically impact on player and the team, regardless of who has control for football related discipline matters. I tend to keep this in my control, as although I'm consisent and fair at all times, I might not want to suspend the star quarterback in bowl week!!